Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

Por Malone, Clare F., Fromm, Jody A., Maertens, Ophélia, DeRaedt, Thomas, Ingraham, Rachel, Cichowski, Karen
Publicado no Cancer Discov (2014)

Molecular Dissection of Isolated Disease Features in Mosaic Neurofibromatosis Type 1

Por Maertens, Ophélia , De Schepper, Sofie , Vandesompele, Jo , Brems, Hilde , Heyns, Ine , Janssens, Sandra , Speleman, Frank , Legius, Eric , Messiaen, Ludwine 
Publicado em 2007

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

Por Lock, Rebecca, Ingraham, Rachel, Maertens, Ophélia, Miller, Abigail L., Weledji, Nelly, Legius, Eric, Konicek, Bruce M., Yan, Sau-Chi B., Graff, Jeremy R., Cichowski, Karen
Publicado no J Clin Invest (2016)

Elucidating distinct roles for NF1 in melanomagenesis

Por Maertens, Ophélia, Johnson, Bryan, Hollstein, Pablo, Frederick, Dennie T., Cooper, Zachary A., Messiaen, Ludwine, Bronson, Roderick T., McMahon, Martin, Granter, Scott, Flaherty, Keith, Wargo, Jennifer A., Marais, Richard, Cichowski, Karen
Publicado em 2012

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy

Por Montero, Joan, Sarosiek, Kristopher A., DeAngelo, Joseph D., Maertens, Ophélia, Ryan, Jeremy, Ercan, Dalia, Piao, Huiying, Horowitz, Neil S., Berkowitz, Ross S., Matulonis, Ursula, Jänne, Pasi A., Amrein, Philip C., Cichowski, Karen, Drapkin, Ronny, Letai, Anthony
Publicado no Cell (2015)

Glomus tumors in neurofibromatosis type 1: genetic, functional and clinical evidence of a novel association

Por Brems, Hilde, Park, Caroline, Maertens, Ophélia, Pemov, Alexander, Messiaen, Ludwine, Upadhyaya, Meena, Claes, Kathleen, Beert, Eline, Peeters, Kristel, Mautner, Victor, Sloan, Jennifer L., Yao, Lawrence, Lee, Chyi-Chia Richard, Sciot, Raf, Smet, Luc De, Legius, Eric, Stewart, Douglas R.
Publicado em 2009

Exploiting cancer cell vulnerabilities to develop a combination therapy for Ras-driven tumors

Por De Raedt, Thomas, Walton, Zandra, Yecies, Jessica L., Li, Danan, Chen, Yimei, Malone, Clare F., Maertens, Ophelia, Jeong, Seung Min, Bronson, Roderick T., Lebleu, Valerie, Kalluri, Raghu, Normant, Emmanuel, Haigis, Marcia C., Manning, Brendan D., Wong, Kwok-Kin, Macleod, Kay F, Cichowski, Karen
Publicado em 2011

Reactivation of ERK Signaling causes resistance to EGFR kinase inhibitors

Por Ercan, Dalia, Xu, Chunxiao, Yanagita, Masahiko, Monast, Calixte S., Pratilas, Christine A., Montero, Joan, Butaney, Mohit, Shimamura, Takeshi, Sholl, Lynette, Ivanova, Elena V., Tadi, Madhavi, Rogers, Andrew, Repellin, Claire, Capelletti, Marzia, Maertens, Ophélia, Goetz, Eva M., Letai, Anthony, Garraway, Levi A., Lazzara, Matthew J., Rosen, Neal, Gray, Nathanael S., Wong, Kwok-Kin, Jänne, Pasi A.
Publicado em 2012