Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

מאת Graham, Richard A, Hop, Cornelis E C A, Borin, Marie T, Lum, Bert L, Colburn, Dawn, Chang, Ilsung, Shin, Young G, Malhi, Vikram, Low, Jennifer A, Dresser, Mark J
יצא לאור 2012

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

מאת Graham, Richard A., Lum, Bert L., Cheeti, Sravanthi, Jin, Jin Yan, Jorga, Karin, Von Hoff, Daniel D., Rudin, Charles M., Reddy, Josina C., Low, Jennifer A., LoRusso, Patricia M.
יצא לאור 2011

An oncogenic NTRK fusion in a soft tissue sarcoma patient with response to the tropomyosin-related kinase (TRK) inhibitor LOXO-101

מאת Doebele, Robert C., Davis, Lara E., Vaishnavi, Aria, Le, Anh T., Estrada-Bernal, Adriana, Keysar, Stephen, Jimeno, Antonio, Varella-Garcia, Marileila, Aisner, Dara L., Li, Yali, Stephens, Philip J., Morosini, Deborah, Tuch, Brian B., Fernandes, Michele, Nanda, Nisha, Low, Jennifer A.
הוצא לאור ב Cancer Discov (2015)

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

מאת Rudin, Charles M., Hann, Christine L., Laterra, John, Yauch, Robert L., Callahan, Christopher A., Fu, Ling, Holcomb, Thomas, Stinson, Jeremy, Gould, Stephen E., Coleman, Barbara, LoRusso, Patricia M., Von Hoff, Daniel D., de Sauvage, Frederic J., Low, Jennifer A.
הוצא לאור ב N Engl J Med (2009)

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

מאת LoRusso, Patricia M., Rudin, Charles M., Reddy, Josina C., Tibes, Raoul, Weiss, Glen J., Borad, Mitesh J., Hann, Christine L., Brahmer, Julie R., Chang, Ilsung, Darbonne, Walter C., Graham, Richard A., Zerivitz, Kenn L., Low, Jennifer A., Von Hoff, Daniel D.
הוצא לאור ב Clin Cancer Res (2011)

Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies

מאת Kummar, Shivaani, Kinders, Robert, Gutierrez, Martin E., Rubinstein, Larry, Parchment, Ralph E., Phillips, Lawrence R., Ji, Jiuping, Monks, Anne, Low, Jennifer A., Chen, Alice, Murgo, Anthony J., Collins, Jerry, Steinberg, Seth M., Eliopoulos, Helen, Giranda, Vincent L., Gordon, Gary, Helman, Lee, Wiltrout, Robert, Tomaszewski, Joseph E., Doroshow, James H.
יצא לאור 2009

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

מאת Yauch, Robert L., Dijkgraaf, Gerrit J. P., Alicke, Bruno, Januario, Thomas, Ahn, Christina P., Holcomb, Thomas, Pujara, Kanan, Stinson, Jeremy, Callahan, Christopher A., Tang, Tracy, Bazan, J. Fernando, Kan, Zhengyan, Seshagiri, Somasekar, Hann, Christine L., Gould, Stephen E., Low, Jennifer A., Rudin, Charles M., de Sauvage, Frederic J.
הוצא לאור ב Science (2009)

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

מאת Sekulic, Aleksandar, Migden, Michael R., Oro, Anthony E., Dirix, Luc, Lewis, Karl D., Hainsworth, John D., Solomon, James A., Yoo, Simon, Arron, Sarah T., Friedlander, Philip A., Marmur, Ellen, Rudin, Charles M., Chang, Anne Lynn S., Low, Jennifer A., Mackey, Howard M., Yauch, Robert L., Graham, Richard A., Reddy, Josina C., Hauschild, Axel
הוצא לאור ב N Engl J Med (2012)