Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

BACKGROUND: Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first...

詳細記述

保存先:
書誌詳細
出版年:N Engl J Med
主要な著者: Sekulic, Aleksandar, Migden, Michael R., Oro, Anthony E., Dirix, Luc, Lewis, Karl D., Hainsworth, John D., Solomon, James A., Yoo, Simon, Arron, Sarah T., Friedlander, Philip A., Marmur, Ellen, Rudin, Charles M., Chang, Anne Lynn S., Low, Jennifer A., Mackey, Howard M., Yauch, Robert L., Graham, Richard A., Reddy, Josina C., Hauschild, Axel
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278761/
https://ncbi.nlm.nih.gov/pubmed/22670903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113713
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