Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

BACKGROUND: Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first...

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發表在:N Engl J Med
Main Authors: Sekulic, Aleksandar, Migden, Michael R., Oro, Anthony E., Dirix, Luc, Lewis, Karl D., Hainsworth, John D., Solomon, James A., Yoo, Simon, Arron, Sarah T., Friedlander, Philip A., Marmur, Ellen, Rudin, Charles M., Chang, Anne Lynn S., Low, Jennifer A., Mackey, Howard M., Yauch, Robert L., Graham, Richard A., Reddy, Josina C., Hauschild, Axel
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278761/
https://ncbi.nlm.nih.gov/pubmed/22670903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113713
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