Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma. A 26-year-old man with metastatic medulloblastoma that was refractory to multiple therapies was trea...

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Bibliografski detalji
Izdano u:N Engl J Med
Glavni autori: Rudin, Charles M., Hann, Christine L., Laterra, John, Yauch, Robert L., Callahan, Christopher A., Fu, Ling, Holcomb, Thomas, Stinson, Jeremy, Gould, Stephen E., Coleman, Barbara, LoRusso, Patricia M., Von Hoff, Daniel D., de Sauvage, Frederic J., Low, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5317279/
https://ncbi.nlm.nih.gov/pubmed/19726761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa0902903
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