Hedgehog Signaling Antagonist GDC-0449 (Vismodegib) Inhibits Pancreatic Cancer Stem Cell Characteristics: Molecular Mechanisms

BACKGROUND: Recent evidence from in vitro and in vivo studies has demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway regulates genes that promote cellular proliferation in various human cancer stem cells (CSCs). Therefore, the chemotherapeutic agents that inhibit a...

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Detalhes bibliográficos
Main Authors: Singh, Brahma N., Fu, Junsheng, Srivastava, Rakesh K., Shankar, Sharmila
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210776/
https://ncbi.nlm.nih.gov/pubmed/22087285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027306
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