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Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines

The sonic hedgehog (Shh) pathway has been proven to be involved in embryonic development and cancer growth. GDC-0449, an antagonist of the hedgehog signaling receptor Smoothened (Smo), was recently approved by the US Food and Drug Administration as a prescription for skin basal cell carcinoma. Howev...

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Detalhes bibliográficos
Publicado no:Exp Ther Med
Main Authors: Wu, Chuanqing, Hu, Shaobo, Cheng, Ji, Wang, Guobin, Tao, Kaixiong
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443192/
https://ncbi.nlm.nih.gov/pubmed/28565875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.4282
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