Effect of the sonic hedgehog inhibitor GDC-0449 on an in vitro isogenic cellular model simulating odontogenic keratocysts

Odontogenic keratocysts (OKCs) are common cystic lesions of odontogenic epithelial origin that can occur sporadically or in association with naevoid basal cell carcinoma syndrome (NBCCS). OKCs are locally aggressive, cause marked destruction of the jaw bones and have a propensity to recur. PTCH1 mut...

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Udgivet i:Int J Oral Sci
Main Authors: Zhai, Jiemei, Zhang, Heyu, Zhang, Jianyun, Zhang, Ran, Hong, Yingying, Qu, Jiafei, Chen, Feng, Li, Tiejun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320367/
https://ncbi.nlm.nih.gov/pubmed/30610186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41368-018-0034-x
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