Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects

por Graham, Richard A, Hop, Cornelis E C A, Borin, Marie T, Lum, Bert L, Colburn, Dawn, Chang, Ilsung, Shin, Young G, Malhi, Vikram, Low, Jennifer A, Dresser, Mark J
Publicado 2012

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

por Graham, Richard A., Lum, Bert L., Cheeti, Sravanthi, Jin, Jin Yan, Jorga, Karin, Von Hoff, Daniel D., Rudin, Charles M., Reddy, Josina C., Low, Jennifer A., LoRusso, Patricia M.
Publicado 2011

An oncogenic NTRK fusion in a soft tissue sarcoma patient with response to the tropomyosin-related kinase (TRK) inhibitor LOXO-101

por Doebele, Robert C., Davis, Lara E., Vaishnavi, Aria, Le, Anh T., Estrada-Bernal, Adriana, Keysar, Stephen, Jimeno, Antonio, Varella-Garcia, Marileila, Aisner, Dara L., Li, Yali, Stephens, Philip J., Morosini, Deborah, Tuch, Brian B., Fernandes, Michele, Nanda, Nisha, Low, Jennifer A.
Publicado en Cancer Discov (2015)

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

por Rudin, Charles M., Hann, Christine L., Laterra, John, Yauch, Robert L., Callahan, Christopher A., Fu, Ling, Holcomb, Thomas, Stinson, Jeremy, Gould, Stephen E., Coleman, Barbara, LoRusso, Patricia M., Von Hoff, Daniel D., de Sauvage, Frederic J., Low, Jennifer A.
Publicado en N Engl J Med (2009)

Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors

por LoRusso, Patricia M., Rudin, Charles M., Reddy, Josina C., Tibes, Raoul, Weiss, Glen J., Borad, Mitesh J., Hann, Christine L., Brahmer, Julie R., Chang, Ilsung, Darbonne, Walter C., Graham, Richard A., Zerivitz, Kenn L., Low, Jennifer A., Von Hoff, Daniel D.
Publicado en Clin Cancer Res (2011)

Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies

por Kummar, Shivaani, Kinders, Robert, Gutierrez, Martin E., Rubinstein, Larry, Parchment, Ralph E., Phillips, Lawrence R., Ji, Jiuping, Monks, Anne, Low, Jennifer A., Chen, Alice, Murgo, Anthony J., Collins, Jerry, Steinberg, Seth M., Eliopoulos, Helen, Giranda, Vincent L., Gordon, Gary, Helman, Lee, Wiltrout, Robert, Tomaszewski, Joseph E., Doroshow, James H.
Publicado 2009

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

por Yauch, Robert L., Dijkgraaf, Gerrit J. P., Alicke, Bruno, Januario, Thomas, Ahn, Christina P., Holcomb, Thomas, Pujara, Kanan, Stinson, Jeremy, Callahan, Christopher A., Tang, Tracy, Bazan, J. Fernando, Kan, Zhengyan, Seshagiri, Somasekar, Hann, Christine L., Gould, Stephen E., Low, Jennifer A., Rudin, Charles M., de Sauvage, Frederic J.
Publicado en Science (2009)

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

por Sekulic, Aleksandar, Migden, Michael R., Oro, Anthony E., Dirix, Luc, Lewis, Karl D., Hainsworth, John D., Solomon, James A., Yoo, Simon, Arron, Sarah T., Friedlander, Philip A., Marmur, Ellen, Rudin, Charles M., Chang, Anne Lynn S., Low, Jennifer A., Mackey, Howard M., Yauch, Robert L., Graham, Richard A., Reddy, Josina C., Hauschild, Axel
Publicado en N Engl J Med (2012)