Discoidin domain receptor functions in physiological and pathological conditions

per Leitinger, Birgit
Publicat 2014

Effects of I Domain Deletion on the Function of the β2 Integrin Lymphocyte Function-associated Antigen-1

per Leitinger, Birgit, Hogg, Nancy
Publicat 2000

Discoidin domain receptors: multitaskers for physiological and pathological processes

per Leitinger, Birgit, Saltel, Frédéric
Publicat a Cell Adh Migr (2018)

Cell-based Assay for Recruitment of DDR1 to Collagen-coated Beads

per Juskaite, Victoria, Leitinger, Birgit
Publicat a Bio Protoc (2019)

Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers

per Juskaite, Victoria, Corcoran, David S, Leitinger, Birgit
Publicat a eLife (2017)

Two-step release of kinase autoinhibition in discoidin domain receptor 1

per Sammon, Douglas, Hohenester, Erhard, Leitinger, Birgit
Publicat a Proc Natl Acad Sci U S A (2020)

DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASES: NEW PLAYERS IN CANCER PROGRESSION

per Valiathan, Rajeshwari R., Marco, Marta, Leitinger, Birgit, Kleer, Celina G., Fridman, Rafael
Publicat 2012

Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1

per Xu, Huifang, Raynal, Nicolas, Stathopoulos, Stavros, Myllyharju, Johanna, Farndale, Richard W., Leitinger, Birgit
Publicat 2011

Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation

per Xu, Huifang, Bihan, Dominique, Chang, Francis, Huang, Paul H., Farndale, Richard W., Leitinger, Birgit
Publicat 2012

Normal Activation of Discoidin Domain Receptor 1 Mutants with Disulfide Cross-links, Insertions, or Deletions in the Extracellular Juxtamembrane Region: MECHANISTIC IMPLICATIONS

per Xu, Huifang, Abe, Takemoto, Liu, Justin K. H., Zalivina, Irina, Hohenester, Erhard, Leitinger, Birgit
Publicat 2014

ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)

per Shitomi, Yasuyuki, Thøgersen, Ida B., Ito, Noriko, Leitinger, Birgit, Enghild, Jan J., Itoh, Yoshifumi
Publicat a Mol Biol Cell (2015)

A novel form of integrin dysfunction involving β1, β2, and β3 integrins

per McDowall, Alison, Inwald, David, Leitinger, Birgit, Jones, Alison, Liesner, Ri, Klein, Nigel, Hogg, Nancy
Publicat 2003

Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

per Hidalgo-Carcedo, Cristina, Hooper, Steven, Chaudhry, Shahid I., Williamson, Peter, Harrington, Kevin, Leitinger, Birgit, Sahai, Erik
Publicat 2010

Crystallographic Insight into Collagen Recognition by Discoidin Domain Receptor 2

per Carafoli, Federico, Bihan, Dominique, Stathopoulos, Stavros, Konitsiotis, Antonios D., Kvansakul, Marc, Farndale, Richard W., Leitinger, Birgit, Hohenester, Erhard
Publicat 2009

DDR1 autophosphorylation is a result of aggregation into dense clusters

per Corcoran, David S., Juskaite, Victoria, Xu, Yuewei, Görlitz, Frederik, Alexandrov, Yuriy, Dunsby, Christopher, French, Paul M. W., Leitinger, Birgit
Publicat a Sci Rep (2019)

Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients

per Ali, Bassam R., Xu, Huifang, Akawi, Nadia A., John, Anne, Karuvantevida, Noushad S., Langer, Ruth, Al-Gazali, Lihadh, Leitinger, Birgit
Publicat 2010

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

per Carafoli, Federico, Mayer, Marie Cathrin, Shiraishi, Kazushige, Pecheva, Mira Anguelova, Chan, Lai Yi, Nan, Ruodan, Leitinger, Birgit, Hohenester, Erhard
Publicat 2012

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor

per An, Bo, Abbonante, Vittorio, Xu, Huifang, Gavriilidou, Despoina, Yoshizumi, Ayumi, Bihan, Dominique, Farndale, Richard W., Kaplan, David L., Balduini, Alessandra, Leitinger, Birgit, Brodsky, Barbara
Publicat a J Biol Chem (2016)

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells

per Rhys, Alexander D., Monteiro, Pedro, Smith, Christopher, Vaghela, Malti, Arnandis, Teresa, Kato, Takuya, Leitinger, Birgit, Sahai, Erik, McAinsh, Andrew, Charras, Guillaume, Godinho, Susana A.
Publicat a J Cell Biol (2018)

Chain Alignment of Collagen I Deciphered using Computationally Designed Heterotrimers

per Jalan, Abhishek A., Sammon, Douglas, Hartgerink, Jeffrey D., Brear, Paul, Stott, Katherine, Hamaia, Samir W., Hunter, Emma J., Walker, Douglas R., Leitinger, Birgit, Farndale, Richard W.
Publicat a Nat Chem Biol (2020)