ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)

Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that binds and transmits signals from various collagens in epithelial cells. However, how DDR1–dependent signaling is regulated has not been understood. Here we report that collagen binding induces ADAM10-dependent ectodomain shedding...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Shitomi, Yasuyuki, Thøgersen, Ida B., Ito, Noriko, Leitinger, Birgit, Enghild, Jan J., Itoh, Yoshifumi
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4325837/
https://ncbi.nlm.nih.gov/pubmed/25540428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-10-1463
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