Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity

Dapagliflozin, empagliflozin, tofogliflozin, selective inhibitors of sodium-glucose cotransporter 2 (SGLT2), is used clinically to reduce circulation glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose by the kidneys. Dapagliflozin is metabolized and inac...

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Gepubliceerd in:Molecules
Hoofdauteurs: Okada, Junichi, Yamada, Eijiro, Saito, Tsugumichi, Yokoo, Hideaki, Osaki, Aya, Shimoda, Yoko, Ozawa, Atsushi, Nakajima, Yasuyo, Pessin, Jeffrey E., Okada, Shuichi, Yamada, Masanobu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038111/
https://ncbi.nlm.nih.gov/pubmed/31979355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25030495
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