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Collagen induces activation of DDR1 through lateral dimer association and phosphorylation between dimers
The collagen-binding receptor tyrosine kinase DDR1 (discoidin domain receptor 1) is a drug target for a wide range of human diseases, but the molecular mechanism of DDR1 activation is poorly defined. Here we co-expressed different types of signalling-incompetent DDR1 mutants (‘receiver’) with functi...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5489314/ https://ncbi.nlm.nih.gov/pubmed/28590245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25716 |
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