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Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells
Centrosome amplification is a common feature of human tumors. To survive, cancer cells cluster extra centrosomes during mitosis, avoiding the detrimental effects of multipolar divisions. However, it is unclear whether clustering requires adaptation or is inherent to all cells. Here, we show that cel...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748979/ https://ncbi.nlm.nih.gov/pubmed/29133484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201704102 |
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