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Two-step release of kinase autoinhibition in discoidin domain receptor 1
Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase with important functions in organogenesis and tissue homeostasis. Aberrant DDR1 activity contributes to the progression of human diseases, including fibrosis and cancer. How DDR1 activity is regulated is poorly under...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7486717/ https://ncbi.nlm.nih.gov/pubmed/32839343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007271117 |
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