Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to Ischemia

per Lee, Yang-ja, Johnson, Kory R., Hallenbeck, John M.
Publicat 2012

A Method for Hypothermia-Induction and Maintenance Allows Precise Body and Brain Temperature Control in Mice

per Mou, Yongshan, Wilgenburg, Brian J., Lee, Yang-ja, Hallenbeck, John M.
Publicat 2012

Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels

per Lee, Yang-ja, Bernstock, Joshua D., Klimanis, Dace, Hallenbeck, John M.
Publicat a Front Mol Neurosci (2018)

Global SUMOylation is a molecular mechanism underlying hypothermia-induced ischemic tolerance

per Lee, Yang-ja, Mou, Yongshan, Klimanis, Dace, Bernstock, Joshua D., Hallenbeck, John M.
Publicat a Front Cell Neurosci (2014)

Global SUMOylation facilitates the multimodal neuroprotection afforded by quercetin against the deleterious effects of oxygen/glucose deprivation and the restoration of oxygen/gluc...

per Lee, Yang-ja, Bernstock, Joshua D., Nagaraja, Nandakumar, Ko, Brian, Hallenbeck, John M.
Publicat a J Neurochem (2016)

Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis

per Lee, Yang-ja, Jeong, Seon-Yong, Karbowski, Mariusz, Smith, Carolyn L., Youle, Richard J.
Publicat 2004

SUMOylation participates in induction of ischemic tolerance

per Lee, Yang-ja, Castri, Paola, Bembry, Joliet, Maric, Dragan, Auh, Sungyoung, Hallenbeck, John M
Publicat 2009

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

per Lee, Yang-ja, Mou, Yongshan, Maric, Dragan, Klimanis, Dace, Auh, Sungyoung, Hallenbeck, John M.
Publicat 2011

Poly(ADP-ribose) polymerase-1 and its cleavage products differentially modulate cellular protection through NF-kB-dependent signaling

per Castri, Paola, Lee, Yang-ja, Ponzio, Todd, Maric, Dragan, Spatz, Maria, Bembry, Joliet, Hallenbeck, John
Publicat 2014

Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells

per Lee, Yang-ja, Miyake, Shin-ichi, Wakita, Hideaki, McMullen, David C, Azuma, Yoshiaki, Auh, Sungyoung, Hallenbeck, John M
Publicat 2006

Drugging SUMOylation for neuroprotection and oncotherapy

per Bernstock, Joshua D., Ye, Daniel G., Lee, Yang-ja, Gessler, Florian, Friedman, Gregory K., Zheng, Wei, Hallenbeck, John M.
Publicat a Neural Regen Res (2018)

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

per Jeong, Seon-Yong, Gaume, Brigitte, Lee, Yang-Ja, Hsu, Yi-Te, Ryu, Seung-Wook, Yoon, Soo-Han, Youle, Richard J
Publicat 2004

Hypophosphorylation of Ribosomal Protein S6 is a Molecular Mechanism Underlying Ischemic Tolerance Induced by either Hibernation or Preconditioning

per Miyake, Shin-ichi, Wakita, Hideaki, Bernstock, Joshua D., Castri, Paola, Ruetzler, Christl, Miyake, Junko, Lee, Yang-ja, Hallenbeck, John M.
Publicat a J Neurochem (2015)

SUMOylation in brain ischemia: Patterns, targets, and translational implications

per Bernstock, Joshua D, Yang, Wei, Ye, Daniel G, Shen, Yuntian, Pluchino, Stefano, Lee, Yang-Ja, Hallenbeck, John M, Paschen, Wulf
Publicat a J Cereb Blood Flow Metab (2017)

Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering

per Bernstock, Joshua D, Peruzzotti-Jametti, Luca, Ye, Daniel, Gessler, Florian A, Maric, Dragan, Vicario, Nunzio, Lee, Yang-Ja, Pluchino, Stefano, Hallenbeck, John M
Publicat a J Cereb Blood Flow Metab (2017)

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

per Karbowski, Mariusz, Lee, Yang-Ja, Gaume, Brigitte, Jeong, Seon-Yong, Frank, Stephan, Nechushtan, Amotz, Santel, Ansgar, Fuller, Margaret, Smith, Carolyn L., Youle, Richard J.
Publicat 2002

Cerebral Ischemia Increases Small Ubiquitin-Like Modifier Conjugation within Human Penumbral Tissue: Radiological–Pathological Correlation

per Bernstock, Joshua D., Ye, Daniel G., Griffin, Allison, Lee, Yang-ja, Lynch, John, Latour, Lawrence L., Friedman, Gregory K., Maric, Dragan, Hallenbeck, John M.
Publicat a Front Neurol (2018)

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a mod...

per Bernstock, Joshua D, Lee, Yang-ja, Peruzzotti-Jametti, Luca, Southall, Noel, Johnson, Kory R, Maric, Dragan, Volpe, Giulio, Kouznetsova, Jennifer, Zheng, Wei, Pluchino, Stefano, Hallenbeck, John M
Publicat a J Cereb Blood Flow Metab (2015)

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

per Bernstock, Joshua D., Ye, Daniel, Gessler, Florian A., Lee, Yang-ja, Peruzzotti-Jametti, Luca, Baumgarten, Peter, Johnson, Kory R., Maric, Dragan, Yang, Wei, Kögel, Donat, Pluchino, Stefano, Hallenbeck, John M.
Publicat a Sci Rep (2017)

Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2

per Bernstock, Joshua D., Ye, Daniel, Smith, Jayden A., Lee, Yang-Ja, Gessler, Florian A., Yasgar, Adam, Kouznetsova, Jennifer, Jadhav, Ajit, Wang, Zhuoran, Pluchino, Stefano, Zheng, Wei, Simeonov, Anton, Hallenbeck, John M., Yang, Wei
Publicat a FASEB J (2018)