Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming

Protein SUMOylation is a dynamic post-translational modification shown to be involved in a diverse set of physiologic processes throughout the cell. SUMOylation has also been shown to play a role in the pathobiology of myriad cancers, one of which is glioblastoma multiforme (GBM). As such, the clini...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bernstock, Joshua D., Ye, Daniel, Gessler, Florian A., Lee, Yang-ja, Peruzzotti-Jametti, Luca, Baumgarten, Peter, Johnson, Kory R., Maric, Dragan, Yang, Wei, Kögel, Donat, Pluchino, Stefano, Hallenbeck, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547153/
https://ncbi.nlm.nih.gov/pubmed/28785061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07631-9
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