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Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

Bcl-x(L) is a potent inhibitor of apoptosis. While Bcl-x(L) can be bound to mitochondria, a substantial fraction, depending on the cell type or tissue, is found in the cytosol of healthy cells. Gel filtration and crosslinking experiments reveal that, unlike monomeric Bax, Bcl-x(L) migrates in a comp...

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Foilsithe in:EMBO J
Main Authors: Jeong, Seon-Yong, Gaume, Brigitte, Lee, Yang-Ja, Hsu, Yi-Te, Ryu, Seung-Wook, Yoon, Soo-Han, Youle, Richard J
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15131699/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600225
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