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Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
Bcl-x(L) is a potent inhibitor of apoptosis. While Bcl-x(L) can be bound to mitochondria, a substantial fraction, depending on the cell type or tissue, is found in the cytosol of healthy cells. Gel filtration and crosslinking experiments reveal that, unlike monomeric Bax, Bcl-x(L) migrates in a comp...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC424420/ https://ncbi.nlm.nih.gov/pubmed/15131699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600225 |
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