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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
The Bcl-2 family member Bax translocates from the cytosol to mitochondria where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis. Bax activity is counteracted by pro-survival Bcl-2 proteins, but how they inhibit Bax remains controversial, because they neither c...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070914/ https://ncbi.nlm.nih.gov/pubmed/21458670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.02.034 |
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