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Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis

The most critical step in the initiation of apoptosis is the activation of the Bcl-2 family of proteins to oligomerize and permeabilize the outer-mitochondrial membrane (OMM). As this step results in the irreversible release of factors that enhance cellular degradation, it is the point of no return...

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Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Gahl, Robert F, Dwivedi, Pallavi, Tjandra, Nico
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133987/
https://ncbi.nlm.nih.gov/pubmed/27763642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.320
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