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Endolysosomal Targeting of Mitochondria is Integral to BAX-mediated Mitochondrial Permeabilization During Apoptosis Signaling
Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis signaling. However, the underlying mechanism of BAX/BAK pore formation remains incompletely understood. Here, we demonstrate that mitochondria are globally and dynamically targeted by endolysosomes (ELs) during MOMP. I...
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| Publicado en: | Dev Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7433306/ https://ncbi.nlm.nih.gov/pubmed/32504557 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.05.014 |
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