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Endolysosomal Targeting of Mitochondria is Integral to BAX-mediated Mitochondrial Permeabilization During Apoptosis Signaling

Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis signaling. However, the underlying mechanism of BAX/BAK pore formation remains incompletely understood. Here, we demonstrate that mitochondria are globally and dynamically targeted by endolysosomes (ELs) during MOMP. I...

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發表在:Dev Cell
Main Authors: Wang, Tim Sen, Coppens, Isabelle, Saorin, Anna, Brady, Nathan Ryan, Hamacher-Brady, Anne
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433306/
https://ncbi.nlm.nih.gov/pubmed/32504557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.05.014
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