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The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria
The proapoptotic Bcl-2 protein Bax can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane. Prosurvival Bcl-2 family members, such as Bcl-x(L), control Bax activity. Bcl-x(L) recognizes Bax after a conformational c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554327/ https://ncbi.nlm.nih.gov/pubmed/23079612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.131 |
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