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The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria

The proapoptotic Bcl-2 protein Bax can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane. Prosurvival Bcl-2 family members, such as Bcl-x(L), control Bax activity. Bcl-x(L) recognizes Bax after a conformational c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Todt, F, Cakir, Z, Reichenbach, F, Youle, R J, Edlich, F
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554327/
https://ncbi.nlm.nih.gov/pubmed/23079612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.131
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