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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
We find that Bax, a proapoptotic member of the Bcl-2 family, translocates to discrete foci on mitochondria during the initial stages of apoptosis, which subsequently become mitochondrial scission sites. A dominant negative mutant of Drp1, Drp1(K38A), inhibits apoptotic scission of mitochondria, but...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173996/ https://ncbi.nlm.nih.gov/pubmed/12499352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209124 |
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