Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

We find that Bax, a proapoptotic member of the Bcl-2 family, translocates to discrete foci on mitochondria during the initial stages of apoptosis, which subsequently become mitochondrial scission sites. A dominant negative mutant of Drp1, Drp1(K38A), inhibits apoptotic scission of mitochondria, but...

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Hlavní autoři: Karbowski, Mariusz, Lee, Yang-Ja, Gaume, Brigitte, Jeong, Seon-Yong, Frank, Stephan, Nechushtan, Amotz, Santel, Ansgar, Fuller, Margaret, Smith, Carolyn L., Youle, Richard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173996/
https://ncbi.nlm.nih.gov/pubmed/12499352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209124
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