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The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division
We identify a mitochondrial E3 ubiquitin ligase, MARCH5, as a critical regulator of mitochondrial fission. MARCH5 RING mutants and MARCH5 RNA interference induce an abnormal elongation and interconnection of mitochondria indicative of an inhibition of mitochondrial division. The aberrant mitochondri...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064424/ https://ncbi.nlm.nih.gov/pubmed/17606867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611064 |
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