A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

Por Lebel, Michel, Leder, Philip
Publicado em 1998

YB-1 promotes strand separation in vitro of duplex DNA containing either mispaired bases or cisplatin modifications, exhibits endonucleolytic activities and binds several DNA repai...

Por Gaudreault, Isabelle, Guay, David, Lebel, Michel
Publicado em 2004

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Por Lachapelle, Sophie, Oesterreich, Steffi, Lebel, Michel
Publicado em 2011

Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin

Por Lebel, Michel, Massip, Laurent, Garand, Chantal, Thorin, Eric
Publicado em 2010

Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span

Por Dallaire, Alexandra, Proulx, Sophie, Simard, Martin J, Lebel, Michel
Publicado no BMC Genomics (2014)

Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice

Por Lebel, Michel, Lavoie, Josée, Gaudreault, Isabelle, Bronsard, Marc, Drouin, Régen
Publicado em 2003

Metabolism, Genomics, and DNA Repair in the Mouse Aging Liver

Por Lebel, Michel, de Souza-Pinto, Nadja C., Bohr, Vilhelm A.
Publicado em 2011

Neurostimulation for fecal incontinence after correction of repair of imperforate anus

Por Bougie, Alexandre, McFadden, Nathalie, Mayer, Sandeep, Lebel, Michel, Devroede, Ghislain
Publicado no World J Clin Cases (2017)

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide

Por Lebel Michel, Garand Chantal, Paquet Éric R, Turaga Ramachander VN, Labbé Adam
Publicado em 2010-02-01

Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide

Por Labbé, Adam, Turaga, Ramachander VN, Paquet, Éric R, Garand, Chantal, Lebel, Michel
Publicado em 2010

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Por Aumailley, Lucie, Garand, Chantal, Dubois, Marie Julie, Johnson, F. Brad, Marette, André, Lebel, Michel
Publicado no PLoS One (2015)

Low expression of the X-linked ribosomal protein S4 in human serous epithelial ovarian cancer is associated with a poor prognosis

Por Tsofack, Serges P, Meunier, Liliane, Sanchez, Lilia, Madore, Jason, Provencher, Diane, Mes-Masson, Anne-Marie, Lebel, Michel
Publicado em 2013

NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines

Por Tsofack, Serges P, Garand, Chantal, Sereduk, Chris, Chow, Donald, Aziz, Meraj, Guay, David, Yin, Hongwei H, Lebel, Michel
Publicado em 2011

Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

Por Dallaire, Alexandra, Garand, Chantal, Paquet, Eric R., Mitchell, Sarah J., de Cabo, Rafael, Simard, Martin J., Lebel, Michel
Publicado em 2012

Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo(−/−) mice

Por Aumailley, Lucie, Warren, Alessandra, Garand, Chantal, Dubois, Marie Julie, Paquet, Eric R., Le Couteur, David G., Marette, André, Cogger, Victoria C., Lebel, Michel
Publicado no Aging (Albany NY) (2016)

Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities

Por Gagné, Jean-Philippe, Lachapelle, Sophie, Garand, Chantal, Tsofack, Serges P., Coulombe, Yan, Caron, Marie-Christine, Poirier, Guy G., Masson, Jean-Yves, Lebel, Michel
Publicado no Oncotarget (2016)

Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Por Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Wu, Ling, Ma, Jin, Kingsley, Charles, Lebel, Michel, Pathak, Sen, DePinho, Ronald A., Chang, Sandy
Publicado em 2005

Proteome-wide Identification of WRN-Interacting Proteins in Untreated and Nuclease-Treated Samples

Por Lachapelle, Sophie, Gagné, Jean-Philippe, Garand, Chantal, Desbiens, Myriam, Coulombe, Yan, Bohr, Vilhelm A, Hendzel, Michael J., Masson, Jean-Yves, Poirier, Guy G., Lebel, Michel
Publicado no J Proteome Res (2011)

Novel DNA mismatch repair activity involving YB-1 in human mitochondria

Por de Souza-Pinto, Nadja C., Mason, Penelope A., Hashiguchi, Kazunari, Weissman, Lior, Tian, Jingyan, Guay, David, Lebel, Michel, Stevnsner, Tinna V., Rasmussen, Lene Juel, Bohr, Vilhelm A.
Publicado em 2009

A 12‐gene signature to distinguish colon cancer patients with better clinical outcome following treatment with 5‐fluorouracil or FOLFIRI

Por Paquet, Eric R., Cui, Jing, Davidson, David, Pietrosemoli, Natalia, Hassan, Houssein Hajj, Tsofack, Serges P., Maltais, Annie, Hallett, Michael T., Delorenzi, Mauro, Batist, Gerald, Aloyz, Raquel, Lebel, Michel
Publicado no J Pathol Clin Res (2015)