Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo(−/−) mice

Suboptimal intake of dietary vitamin C (ascorbate) increases the risk of several chronic diseases but the exact metabolic pathways affected are still unknown. In this study, we examined the metabolic profile of mice lacking the enzyme gulonolactone oxidase (Gulo) required for the biosynthesis of asc...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Aumailley, Lucie, Warren, Alessandra, Garand, Chantal, Dubois, Marie Julie, Paquet, Eric R., Le Couteur, David G., Marette, André, Cogger, Victoria C., Lebel, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833140/
https://ncbi.nlm.nih.gov/pubmed/26922388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100902
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