Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase (WRN). Mice lacking part of the helicase domain of the WRN ortholog exhibit several phenotypic features of WS. In this study, we generated a Wrn mutant line that, like humans, relies entirely on diet...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Aumailley, Lucie, Dubois, Marie Julie, Brennan, Tracy A., Garand, Chantal, Paquet, Eric R., Pignolo, Robert J., Marette, André, Lebel, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998970/
https://ncbi.nlm.nih.gov/pubmed/29452565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701176R
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