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Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Aumailley, Lucie, Garand, Chantal, Dubois, Marie Julie, Johnson, F. Brad, Marette, André, Lebel, Michel
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598085/
https://ncbi.nlm.nih.gov/pubmed/26447695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140292
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