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Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

Small non-coding microRNAs are believed to be involved in the mechanism of aging but nothing is known on the impact of microRNAs in the progeroid disorder Werner syndrome (WS). WS is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the W...

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Bibliografiska uppgifter
Huvudupphovsmän: Dallaire, Alexandra, Garand, Chantal, Paquet, Eric R., Mitchell, Sarah J., de Cabo, Rafael, Simard, Martin J., Lebel, Michel
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492227/
https://ncbi.nlm.nih.gov/pubmed/23075628
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