Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter mean life span. In contrast, mice lacking...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Aumailley, Lucie, Garand, Chantal, Dubois, Marie Julie, Johnson, F. Brad, Marette, André, Lebel, Michel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598085/
https://ncbi.nlm.nih.gov/pubmed/26447695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140292
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