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Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin

Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS. Importantly, mutant Wrn(Δ)(hel)(/Δ)(hel) mice show abnormal increases in visceral fat deposition and fasti...

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Detalhes bibliográficos
Main Authors: Lebel, Michel, Massip, Laurent, Garand, Chantal, Thorin, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693984/
https://ncbi.nlm.nih.gov/pubmed/20536831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2010.05189.x
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