Elevated Airway Purines in COPD

par Esther, Charles R., Lazaar, Aili L., Bordonali, Elena, Qaqish, Bahjat, Boucher, Richard C.
Publié 2011

The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma

par Macdonald Alex J, Petavy Frank, Singh Dave, Lazaar Aili L, O'Connor Brian J
Publié 2010-03-01

The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma

par Singh, Dave, Petavy, Frank, Macdonald, Alex J, Lazaar, Aili L, O'Connor, Brian J
Publié 2010

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

par Lazaar, Aili L, Sweeney, Lisa E, MacDonald, Alexander J, Alexis, Neil E, Chen, Chao, Tal-Singer, Ruth
Publié 2011

Assessment of potential drug interactions by characterization of human drug metabolism pathways using non-invasive bile sampling

par Bloomer, Jackie C, Nash, Mike, Webb, Alison, Miller, Bruce E, Lazaar, Aili L, Beaumont, Claire, Guiney, William J
Publié 2013

CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial

par Lazaar, Aili L., Miller, Bruce E., Donald, Alison C., Keeley, Thomas, Ambery, Claire, Russell, John, Watz, Henrik, Tal-Singer, Ruth
Publié dans Respir Res (2020)

Pharmacokinetics, Excretion, and Mass Balance of [(14)C]‐Batefenterol Following a Single Microtracer Intravenous Dose (Concomitant to an Inhaled Dose) or Oral Dose of Batefenterol...

par Ambery, Claire, Young, Graeme, Fuller, Teresa, Lazaar, Aili L., Pereira, Adrian, Hughes, Adam, Ramsay, David, van den Berg, Frans, Daley‐Yates, Peter
Publié dans Clin Pharmacol Drug Dev (2018)

The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects

par Miller, Bruce E., Mistry, Sunil, Smart, Kevin, Connolly, Paul, Carpenter, Donald C., Cooray, Hiran, Bloomer, Jackie C., Tal-Singer, Ruth, Lazaar, Aili L.
Publié dans BMC Pharmacol Toxicol (2015)

Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660)

par Miller, Bruce E., Mayer, Ruth J., Goyal, Navin, Bal, Joanne, Dallow, Nigel, Boyce, Malcolm, Carpenter, Donald, Churchill, Alison, Heslop, Teresa, Lazaar, Aili L.
Publié dans Br J Clin Pharmacol (2017)

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

par Keir, Holly R., Richardson, Hollian, Fillmore, Christina, Shoemark, Amelia, Lazaar, Aili L., Miller, Bruce E., Tal-Singer, Ruth, Chalmers, James D., Mohan, Divya
Publié dans ERJ Open Res (2020)

The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers

par Miller, Bruce E., Smart, Kevin, Mistry, Sunil, Ambery, Claire L., Bloomer, Jackie C., Connolly, Paul, Sanderson, Dominic, Shreeves, Trevor, Smith, Rachel, Lazaar, Aili L.
Publié 2014

Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers

par Yang, Lucy, Cheriyan, Joseph, Gutterman, David D., Mayer, Ruth J., Ament, Zsuzsanna, Griffin, Jules L., Lazaar, Aili L., Newby, David E., Tal-Singer, Ruth, Wilkinson, Ian B.
Publié dans Chest (2017)

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

par Lazaar, Aili L., Yang, Lucy, Boardley, Rebecca L., Goyal, Navin S., Robertson, Jonathan, Baldwin, Sandra J., Newby, David E., Wilkinson, Ian B., Tal‐Singer, Ruth, Mayer, Ruth J., Cheriyan, Joseph
Publié dans Br J Clin Pharmacol (2016)

Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study

par Hall, David A., Hanrott, Kate, Badorrek, Philipp, Berliner, Dominik, Budd, David C., Eames, Rhena, Powley, William M., Hewens, Deborah, Siederer, Sarah, Lazaar, Aili L., Cahn, Anthony, Hohlfeld, Jens M.
Publié dans Pulm Ther (2021)

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome

par Khan, Akram, Benthin, Cody, Zeno, Brian, Albertson, Timothy E., Boyd, John, Christie, Jason D., Hall, Richard, Poirier, Germain, Ronco, Juan J., Tidswell, Mark, Hardes, Kelly, Powley, William M., Wright, Tracey J., Siederer, Sarah K., Fairman, David A., Lipson, David A., Bayliffe, Andrew I., Lazaar, Aili L.
Publié dans Crit Care (2017)

A nebulised antitumour necrosis factor receptor-1 domain antibody in patients at risk of postoperative lung injury: A randomised, placebo-controlled pilot study

par Ryan, James, Bayliffe, Andrew I., McAuley, Daniel F., Yeung, Joyce, Thickett, David R., Howells, Phillip A., O’Donnell, Ciara, Vassallo, Arlette M., Wright, Tracey J., McKie, Elizabeth, Hardes, Kelly, Summers, Charlotte, Shields, Martin O., Powley, William, Wilson, Robert, Lazaar, Aili L., Fowler, Andrew, Perkins, Gavin D.
Publié dans Eur J Anaesthesiol (2020)

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study

par Anderson, Brian J., Calfee, Carolyn S., Liu, Kathleen D., Reilly, John P., Kangelaris, Kirsten N., Shashaty, Michael G. S., Lazaar, Aili L., Bayliffe, Andrew I., Gallop, Robert J., Miano, Todd A., Dunn, Thomas G., Johansson, Erik, Abbott, Jason, Jauregui, Alejandra, Deiss, Thomas, Vessel, Kathryn, Belzer, Annika, Zhuo, Hanjing, Matthay, Michael A., Meyer, Nuala J., Christie, Jason D.
Publié dans Crit Care (2019)

Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort

par Stott-Miller, Marni, Müllerová, Hana, Miller, Bruce, Tabberer, Maggie, El Baou, Céline, Keeley, Tom, Martinez, Fernando J, Han, Meilan, Dransfield, Mark, Hansel, Nadia N, Cooper, Christopher B, Woodruff, Prescott, Ortega, Victor E, Comellas, Alejandro P, Paine III, Robert, Kanner, Richard E, Anderson, Wayne, Drummond, M Bradley, Kim, Victor, Tal-Singer, Ruth, Lazaar, Aili L
Publié dans Int J Chron Obstruct Pulmon Dis (2020)