SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

AIMS: To determine the safety and tolerability of a novel selective CXCR2 antagonist and assess its pharmacodynamic effects using measures of neutrophil activation and function, including CD11b expression in whole blood and ozone-induced airway inflammation in healthy subjects. METHODS: Flow cytomet...

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Detalhes bibliográficos
Main Authors: Lazaar, Aili L, Sweeney, Lisa E, MacDonald, Alexander J, Alexis, Neil E, Chen, Chao, Tal-Singer, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Uropharmacology Themed Section
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162658/
https://ncbi.nlm.nih.gov/pubmed/21426372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.03968.x
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