The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) − a selective CXCR2 antagonist − in healthy adult subjects

BACKGROUND: Excessive neutrophil presence and activation is important in a number of acute and chronic inflammatory diseases. The CXCR2 chemokine receptor is important in controlling the extravasation and activation of neutrophils. Selective antagonism of the CXCR2 receptor is a potential approach t...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Miller, Bruce E., Mistry, Sunil, Smart, Kevin, Connolly, Paul, Carpenter, Donald C., Cooray, Hiran, Bloomer, Jackie C., Tal-Singer, Ruth, Lazaar, Aili L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4475328/
https://ncbi.nlm.nih.gov/pubmed/26092545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0017-x
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