20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice

BACKGROUND: Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ozone-induced AHR in murine airways. METHODOLOGY/PRINCIPAL FINDINGS: Male BALB/c m...

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Main Authors: Cooper, Philip R., Mesaros, A. Clementina, Zhang, Jie, Christmas, Peter, Stark, Christopher M., Douaidy, Karim, Mittelman, Michael A., Soberman, Roy J., Blair, Ian A., Panettieri, Reynold A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857875/
https://ncbi.nlm.nih.gov/pubmed/20422032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010235
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