Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Alter Ozone-Induced Airway Hyper-Responsiveness

Nonsteroidal anti-inflammatory drugs ameliorate pain and fever by inhibiting cyclooxygenase (COX) and suppressing prostanoid formation. Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes formation of PGE(2) from the COX product PGH(2) and has emerged as a therapeutic target. Inhibition of mPG...

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Autori principali: Wang, Miao, Cooper, Philip R., Jiang, Meiqi, Zhao, Hengjiang, Hui, Yiqun, Yao, Yubing, Tate, Joshua C., Damera, Gautam, Lawson, John A., Jester, William F., Haczku, Angela, Panettieri, Reynold A., FitzGerald, Garret A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2010
Soggetti:
Inflammation, Immunopharmacology, and Asthma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912039/
https://ncbi.nlm.nih.gov/pubmed/20371706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166678
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