The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

af Bosmans, Laura A., Bosch, Lena, Kusters, Pascal J.H., Lutgens, Esther, Seijkens, Tom T.P.
Udgivet i J Cardiovasc Transl Res (2020)

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

af Poels, Kikkie, van Leent, Mandy M. T., Reiche, Myrthe E., Kusters, Pascal J. H., Huveneers, Stephan, de Winther, Menno P. J., Mulder, Willem J. M., Lutgens, Esther, Seijkens, Tom T. P.
Udgivet i Cells (2020)

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

af Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther
Udgivet i J Pathol (2019)

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

af Aarts, Suzanne A. B. M., Seijkens, Tom T. P., Kusters, Pascal J. H., van der Pol, Susanne M. A., Zarzycka, Barbara, Heijnen, Priscilla D. A. M., Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J. J., Boon, Louis, Weber, Christian, de Vries, Helga E., Nicolaes, Gerry A. F., Dijkstra, Christine D., Kooij, Gijs, Lutgens, Esther
Udgivet i J Neuroinflammation (2017)

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death

af Seijkens, Tom T P, Poels, Kikkie, Meiler, Svenja, van Tiel, Claudia M, Kusters, Pascal J H, Reiche, Myrthe, Atzler, Dorothee, Winkels, Holger, Tjwa, Marc, Poelman, Hessel, Slütter, Bram, Kuiper, Johan, Gijbels, Marion, Kuivenhoven, Jan Albert, Matic, Ljubica Perisic, Paulsson-Berne, Gabrielle, Hedin, Ulf, Hansson, Göran K, Nicolaes, Gerry A F, Daemen, Mat J A P, Weber, Christian, Gerdes, Norbert, de Winther, Menno P J, Lutgens, Esther
Udgivet i Eur Heart J (2019)

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

af Chen, Pei-Yu, Qin, Lingfeng, Li, Guangxin, Wang, Zheng, Dahlman, James E., Malagon-Lopez, Jose, Gujja, Sharvari, Cilfone, Nicholas A., Kauffman, Kevin J., Sun, Lele, Sun, Hongye, Zhang, Xinbo, Aryal, Binod, Canfran-Duque, Alberto, Liu, Rebecca, Kusters, Pascal, Sehgal, Alfica, Jiao, Yang, Anderson, Daniel G., Gulcher, Jeffrey, Fernandez-Hernando, Carlos, Lutgens, Esther, Schwartz, Martin A., Pober, Jordan S., Chittenden, Thomas W., Tellides, George, Simons, Michael
Udgivet i Nat Metab (2019)

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

af Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther
Udgivet i Nat Commun (2021)

Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies

af Döring, Yvonne, Noels, Heidi, van der Vorst, Emiel P.C., Neideck, Carlos, Egea, Virginia, Drechsler, Maik, Mandl, Manuela, Pawig, Lukas, Jansen, Yvonne, Schröder, Katrin, Bidzhekov, Kiril, Megens, Remco T.A., Theelen, Wendy, Klinkhammer, Barbara M., Boor, Peter, Schurgers, Leon, van Gorp, Rick, Ries, Christian, Kusters, Pascal J.H., van der Wal, Allard, Hackeng, Tilman M., Gäbel, Gabor, Brandes, Ralf P., Soehnlein, Oliver, Lutgens, Esther, Vestweber, Dietmar, Teupser, Daniel, Holdt, Lesca M., Rader, Daniel J., Saleheen, Danish, Weber, Christian
Udgivet i Circulation (2017)

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

af Chatzigeorgiou, Antonios, Seijkens, Tom, Zarzycka, Barbara, Engel, David, Poggi, Marjorie, van den Berg, Susan, van den Berg, Sjoerd, Soehnlein, Oliver, Winkels, Holger, Beckers, Linda, Lievens, Dirk, Driessen, Ann, Kusters, Pascal, Biessen, Erik, Garcia-Martin, Ruben, Klotzsche-von Ameln, Anne, Gijbels, Marion, Noelle, Randolph, Boon, Louis, Hackeng, Tilman, Schulte, Klaus-Martin, Xu, Aimin, Vriend, Gert, Nabuurs, Sander, Chung, Kyoung-Jin, Willems van Dijk, Ko, Rensen, Patrick C. N., Gerdes, Norbert, de Winther, Menno, Block, Norman L., Schally, Andrew V., Weber, Christian, Bornstein, Stefan R., Nicolaes, Gerry, Chavakis, Triantafyllos, Lutgens, Esther
Udgivet 2014

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

af Seijkens, Tom T.P., van Tiel, Claudia M., Kusters, Pascal J.H., Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A.B.M., Lameijer, Marnix, Gijbels, Marion J., Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T.A., van ‘t Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A., Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D., Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A., Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P.J., Nicolaes, Gerry A., Mulder, Willem J.M., Weber, Christian, Lutgens, Esther
Udgivet i J Am Coll Cardiol (2018)