Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

BACKGROUND: Disrupting the costimulatory CD40-CD40L dyad reduces atherosclerosis, but can result in immune suppression. The authors recently identified small molecule inhibitors that block the interaction between CD40 and tumor necrosis factor receptor-associated factor (TRAF) 6 (TRAF-STOPs), while...

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Publicat a:J Am Coll Cardiol
Autors principals: Seijkens, Tom T.P., van Tiel, Claudia M., Kusters, Pascal J.H., Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A.B.M., Lameijer, Marnix, Gijbels, Marion J., Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T.A., van ‘t Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A., Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D., Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A., Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P.J., Nicolaes, Gerry A., Mulder, Willem J.M., Weber, Christian, Lutgens, Esther
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Biomedical 2018
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800892/
https://ncbi.nlm.nih.gov/pubmed/29406859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2017.11.055
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