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Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

BACKGROUND: The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the blood-brain barrier (BBB) are therefore regarded as promising therapeutic appr...

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發表在:J Neuroinflammation
Main Authors: Aarts, Suzanne A. B. M., Seijkens, Tom T. P., Kusters, Pascal J. H., van der Pol, Susanne M. A., Zarzycka, Barbara, Heijnen, Priscilla D. A. M., Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J. J., Boon, Louis, Weber, Christian, de Vries, Helga E., Nicolaes, Gerry A. F., Dijkstra, Christine D., Kooij, Gijs, Lutgens, Esther
格式: Artigo
語言:Inglês
出版: BioMed Central 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427621/
https://ncbi.nlm.nih.gov/pubmed/28494768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0875-9
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