Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction

Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced inflammation. Genetic deficiency of CD40L in diet-induced obesity (DIO) ameliorates adipose tissue inflammation, hepatic steatosis and increases i...

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Pubblicato in:PLoS One
Autori principali: Aarts, Suzanne A. B. M., Reiche, Myrthe E., den Toom, Myrthe, Beckers, Linda, Gijbels, Marion J. J., Gerdes, Norbert, de Winther, Menno P. J., Lutgens, Esther
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086432/
https://ncbi.nlm.nih.gov/pubmed/30096208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202150
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