Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although not exhibiting increased weight gain, male CD...

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Main Authors: Chatzigeorgiou, Antonios, Seijkens, Tom, Zarzycka, Barbara, Engel, David, Poggi, Marjorie, van den Berg, Susan, van den Berg, Sjoerd, Soehnlein, Oliver, Winkels, Holger, Beckers, Linda, Lievens, Dirk, Driessen, Ann, Kusters, Pascal, Biessen, Erik, Garcia-Martin, Ruben, Klotzsche-von Ameln, Anne, Gijbels, Marion, Noelle, Randolph, Boon, Louis, Hackeng, Tilman, Schulte, Klaus-Martin, Xu, Aimin, Vriend, Gert, Nabuurs, Sander, Chung, Kyoung-Jin, Willems van Dijk, Ko, Rensen, Patrick C. N., Gerdes, Norbert, de Winther, Menno, Block, Norman L., Schally, Andrew V., Weber, Christian, Bornstein, Stefan R., Nicolaes, Gerry, Chavakis, Triantafyllos, Lutgens, Esther
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932883/
https://ncbi.nlm.nih.gov/pubmed/24492375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400419111
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