The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

gan Bosmans, Laura A., Bosch, Lena, Kusters, Pascal J.H., Lutgens, Esther, Seijkens, Tom T.P.
Cyhoeddwyd yn J Cardiovasc Transl Res (2020)

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

gan Poels, Kikkie, van Leent, Mandy M. T., Reiche, Myrthe E., Kusters, Pascal J. H., Huveneers, Stephan, de Winther, Menno P. J., Mulder, Willem J. M., Lutgens, Esther, Seijkens, Tom T. P.
Cyhoeddwyd yn Cells (2020)

Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis

gan Aarts, Suzanne ABM, Seijkens, Tom TP, Kusters, Pascal JH, van Tiel, Claudia M, Reiche, Myrthe E, den Toom, Myrthe, Beckers, Linda, van Roomen, Cindy PAA, de Winther, Menno PJ, Kooij, Gijs, Lutgens, Esther
Cyhoeddwyd yn J Pathol (2019)

Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

gan Aarts, Suzanne A. B. M., Seijkens, Tom T. P., Kusters, Pascal J. H., van der Pol, Susanne M. A., Zarzycka, Barbara, Heijnen, Priscilla D. A. M., Beckers, Linda, den Toom, Myrthe, Gijbels, Marion J. J., Boon, Louis, Weber, Christian, de Vries, Helga E., Nicolaes, Gerry A. F., Dijkstra, Christine D., Kooij, Gijs, Lutgens, Esther
Cyhoeddwyd yn J Neuroinflammation (2017)

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8(+) T cell-mediated macrophage death

gan Seijkens, Tom T P, Poels, Kikkie, Meiler, Svenja, van Tiel, Claudia M, Kusters, Pascal J H, Reiche, Myrthe, Atzler, Dorothee, Winkels, Holger, Tjwa, Marc, Poelman, Hessel, Slütter, Bram, Kuiper, Johan, Gijbels, Marion, Kuivenhoven, Jan Albert, Matic, Ljubica Perisic, Paulsson-Berne, Gabrielle, Hedin, Ulf, Hansson, Göran K, Nicolaes, Gerry A F, Daemen, Mat J A P, Weber, Christian, Gerdes, Norbert, de Winther, Menno P J, Lutgens, Esther
Cyhoeddwyd yn Eur Heart J (2019)

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

gan Chen, Pei-Yu, Qin, Lingfeng, Li, Guangxin, Wang, Zheng, Dahlman, James E., Malagon-Lopez, Jose, Gujja, Sharvari, Cilfone, Nicholas A., Kauffman, Kevin J., Sun, Lele, Sun, Hongye, Zhang, Xinbo, Aryal, Binod, Canfran-Duque, Alberto, Liu, Rebecca, Kusters, Pascal, Sehgal, Alfica, Jiao, Yang, Anderson, Daniel G., Gulcher, Jeffrey, Fernandez-Hernando, Carlos, Lutgens, Esther, Schwartz, Martin A., Pober, Jordan S., Chittenden, Thomas W., Tellides, George, Simons, Michael
Cyhoeddwyd yn Nat Metab (2019)

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease

gan Lacy, Michael, Bürger, Christina, Shami, Annelie, Ahmadsei, Maiwand, Winkels, Holger, Nitz, Katrin, van Tiel, Claudia M., Seijkens, Tom T. P., Kusters, Pascal J. H., Karshovka, Ela, Prange, Koen H. M., Wu, Yuting, Brouns, Sanne L. N., Unterlugauer, Sigrid, Kuijpers, Marijke J. E., Reiche, Myrthe E., Steffens, Sabine, Edsfeldt, Andreas, Megens, Remco T. A., Heemskerk, Johan W. M., Goncalves, Isabel, Weber, Christian, Gerdes, Norbert, Atzler, Dorothee, Lutgens, Esther
Cyhoeddwyd yn Nat Commun (2021)

Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies

gan Döring, Yvonne, Noels, Heidi, van der Vorst, Emiel P.C., Neideck, Carlos, Egea, Virginia, Drechsler, Maik, Mandl, Manuela, Pawig, Lukas, Jansen, Yvonne, Schröder, Katrin, Bidzhekov, Kiril, Megens, Remco T.A., Theelen, Wendy, Klinkhammer, Barbara M., Boor, Peter, Schurgers, Leon, van Gorp, Rick, Ries, Christian, Kusters, Pascal J.H., van der Wal, Allard, Hackeng, Tilman M., Gäbel, Gabor, Brandes, Ralf P., Soehnlein, Oliver, Lutgens, Esther, Vestweber, Dietmar, Teupser, Daniel, Holdt, Lesca M., Rader, Daniel J., Saleheen, Danish, Weber, Christian
Cyhoeddwyd yn Circulation (2017)

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

gan Chatzigeorgiou, Antonios, Seijkens, Tom, Zarzycka, Barbara, Engel, David, Poggi, Marjorie, van den Berg, Susan, van den Berg, Sjoerd, Soehnlein, Oliver, Winkels, Holger, Beckers, Linda, Lievens, Dirk, Driessen, Ann, Kusters, Pascal, Biessen, Erik, Garcia-Martin, Ruben, Klotzsche-von Ameln, Anne, Gijbels, Marion, Noelle, Randolph, Boon, Louis, Hackeng, Tilman, Schulte, Klaus-Martin, Xu, Aimin, Vriend, Gert, Nabuurs, Sander, Chung, Kyoung-Jin, Willems van Dijk, Ko, Rensen, Patrick C. N., Gerdes, Norbert, de Winther, Menno, Block, Norman L., Schally, Andrew V., Weber, Christian, Bornstein, Stefan R., Nicolaes, Gerry, Chavakis, Triantafyllos, Lutgens, Esther
Cyhoeddwyd 2014

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

gan Seijkens, Tom T.P., van Tiel, Claudia M., Kusters, Pascal J.H., Atzler, Dorothee, Soehnlein, Oliver, Zarzycka, Barbara, Aarts, Suzanne A.B.M., Lameijer, Marnix, Gijbels, Marion J., Beckers, Linda, den Toom, Myrthe, Slütter, Bram, Kuiper, Johan, Duchene, Johan, Aslani, Maria, Megens, Remco T.A., van ‘t Veer, Cornelis, Kooij, Gijs, Schrijver, Roy, Hoeksema, Marten A., Boon, Louis, Fay, Francois, Tang, Jun, Baxter, Samantha, Jongejan, Aldo, Moerland, Perry D., Vriend, Gert, Bleijlevens, Boris, Fisher, Edward A., Duivenvoorden, Raphael, Gerdes, Norbert, de Winther, Menno P.J., Nicolaes, Gerry A., Mulder, Willem J.M., Weber, Christian, Lutgens, Esther
Cyhoeddwyd yn J Am Coll Cardiol (2018)