Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

por Falck, David, Thomann, Marco, Lechmann, Martin, Koeleman, Carolien A. M., Malik, Sebastian, Jany, Cordula, Wuhrer, Manfred, Reusch, Dietmar
Publicado en MAbs (2020)

Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies

por Sonneveld, Myrthe E., Koeleman, Carolien A. M., Plomp, H. Rosina, Wuhrer, Manfred, van der Schoot, C. Ellen, Vidarsson, Gestur
Publicado en Front Immunol (2018)

The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans

por Link-Lenczowski, Paweł, Bubka, Monika, Balog, Crina I. A., Koeleman, Carolien A. M., Butters, Terry D., Wuhrer, Manfred, Lityńska, Anna
Publicado en Glycoconj J (2018)

N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation

por Stavenhagen, Kathrin, Kayili, H. Mehmet, Holst, Stephanie, Koeleman, Carolien A. M., Engel, Ruchira, Wouters, Diana, Zeerleder, Sacha, Salih, Bekir, Wuhrer, Manfred
Publicado en Mol Cell Proteomics (2018)

A novel Gal(beta1-4)Gal(beta1-4)Fuc(alpha1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans.

por Wuhrer, Manfred, Robijn, Marjolein L M, Koeleman, Carolien A M, Balog, Crina I A, Geyer, Rudolf, Deelder, André M, Hokke, Cornelis H
Publicado 2004

Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans

por Dekkers, Gillian, Plomp, Rosina, Koeleman, Carolien A. M., Visser, Remco, von Horsten, Hans H., Sandig, Volker, Rispens, Theo, Wuhrer, Manfred, Vidarsson, Gestur
Publicado en Sci Rep (2016)

Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

por Kemna, Michael J., Plomp, Rosina, van Paassen, Pieter, Koeleman, Carolien A.M., Jansen, Bas C., Damoiseaux, Jan G.M.C., Cohen Tervaert, Jan Willem, Wuhrer, Manfred
Publicado en EBioMedicine (2017)

Targeted Glycoproteomic Analysis Reveals That Kappa-5 is a Major, Uniquely Glycosylated Component of Schistosoma mansoni Egg Antigens

por Meevissen, Moniek H. J., Balog, Crina I. A., Koeleman, Carolien A. M., Doenhoff, Michael J., Schramm, Gabriele, Haas, Helmut, Deelder, André M., Wuhrer, Manfred, Hokke, Cornelis H.
Publicado 2011

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

por Einarsdottir, Helga K., Selman, Maurice H. J., Kapur, Rick, Scherjon, Sicco, Koeleman, Carolien A. M., Deelder, André M., van der Schoot, C. Ellen, Vidarsson, Gestur, Wuhrer, Manfred
Publicado 2012

Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus

por Hewitson, James P., Nguyen, D. Linh, van Diepen, Angela, Smit, Cornelis H., Koeleman, Carolien A., McSorley, Henry J., Murray, Janice, Maizels, Rick M., Hokke, Cornelis H.
Publicado en Int J Parasitol (2016)

Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3)

por Plomp, Rosina, Dekkers, Gillian, Rombouts, Yoann, Visser, Remco, Koeleman, Carolien A.M., Kammeijer, Guinevere S.M., Jansen, Bas C., Rispens, Theo, Hensbergen, Paul J., Vidarsson, Gestur, Wuhrer, Manfred
Publicado en Mol Cell Proteomics (2015)

Anti-D monoclonal antibodies from 23 human and rodent cell lines display diverse IgG Fc-glycosylation profiles that determine their clinical efficacy

por Kumpel, Belinda M., Saldova, Radka, Koeleman, Carolien A. M., Abrahams, Jodie L., Ederveen, Agnes Hipgrave, Armour, Kathryn L., Olovnikova, Natalia I., Vidarsson, Gestur, Kapur, Rick, Rudd, Pauline M., Wuhrer, Manfred
Publicado en Sci Rep (2020)

Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity

por Ruhaak, L. Renee, Uh, Hae-Won, Beekman, Marian, Koeleman, Carolien A. M., Hokke, Cornelis H., Westendorp, Rudi G. J., Wuhrer, Manfred, Houwing-Duistermaat, Jeanine J., Slagboom, P. Eline, Deelder, André M.
Publicado 2010

Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli

por Wang, Jun, Balog, Crina I. A., Stavenhagen, Kathrin, Koeleman, Carolien A. M., Scherer, Hans Ulrich, Selman, Maurice H. J., Deelder, André M., Huizinga, Tom W. J., Toes, René E. M., Wuhrer, Manfred
Publicado 2011

N-glycosylation of Colorectal Cancer Tissues: A LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY-BASED INVESTIGATION

por Balog, Crina I. A., Stavenhagen, Kathrin, Fung, Wesley L. J., Koeleman, Carolien A., McDonnell, Liam A., Verhoeven, Aswin, Mesker, Wilma E., Tollenaar, Rob A. E. M., Deelder, André M., Wuhrer, Manfred
Publicado 2012

Unique patterns of glycosylation in immunoglobulin subclass G4‐related disease and primary sclerosing cholangitis

por Culver, Emma L, van de Bovenkamp, Fleur S, Derksen, Ninotska I L, Koers, Jana, Cargill, Tamsin, Barnes, Eleanor, de Neef, Louise A, Koeleman, Carolien A M, Aalberse, Rob C, Wuhrer, Manfred, Rispens, Theo
Publicado en J Gastroenterol Hepatol (2018)

Targeted Biomarker Discovery by High Throughput Glycosylation Profiling of Human Plasma Alpha1-Antitrypsin and Immunoglobulin A

por Ruhaak, L. Renee, Koeleman, Carolien A. M., Uh, Hae-Won, Stam, Jord C., van Heemst, Diana, Maier, Andrea B., Houwing-Duistermaat, Jeanine J., Hensbergen, Paul J., Slagboom, P. Eline, Deelder, André M., Wuhrer, Manfred
Publicado 2013

Investigations on Aberrant Glycosylation of Glycosphingolipids in Colorectal Cancer Tissues Using Liquid Chromatography and Matrix-Assisted Laser Desorption Time-of-Flight Mass Spe...

por Holst, Stephanie, Stavenhagen, Kathrin, Balog, Crina I. A., Koeleman, Carolien A. M., McDonnell, Liam M., Mayboroda, Oleg A., Verhoeven, Aswin, Mesker, Wilma E., Tollenaar, Rob A. E. M., Deelder, André M., Wuhrer, Manfred
Publicado 2013

N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression

por Holst, Stephanie, Deuss, Anna J. M., van Pelt, Gabi W., van Vliet, Sandra J., Garcia-Vallejo, Juan J., Koeleman, Carolien A. M., Deelder, André M., Mesker, Wilma E., Tollenaar, Rob A., Rombouts, Yoann, Wuhrer, Manfred
Publicado en Mol Cell Proteomics (2016)

Simultaneous Immunoglobulin A and G Glycopeptide Profiling for High-Throughput Applications

por Momčilović, Ana, de Haan, Noortje, Hipgrave Ederveen, Agnes L., Bondt, Albert, Koeleman, Carolien A. M., Falck, David, de Neef, Louise A., Mesker, Wilma E., Tollenaar, Rob, de Ru, Arnoud, van Veelen, Peter, Wuhrer, Manfred, Dotz, Viktoria
Publicado en Anal Chem (2020)