Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody

Good pharmacokinetic (PK) behavior is a key prerequisite for sufficient efficacy of therapeutic monoclonal antibodies (mAbs). Fc glycosylation is a critical quality attribute (CQA) of mAbs, due to its impact on stability and effector functions. However, the effects of various IgG Fc glycoforms on an...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Falck, David, Thomann, Marco, Lechmann, Martin, Koeleman, Carolien A. M., Malik, Sebastian, Jany, Cordula, Wuhrer, Manfred, Reusch, Dietmar
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781607/
https://ncbi.nlm.nih.gov/pubmed/33382957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1865596
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