Myo-Glyco disease Biology: Genetic Myopathies Caused by Abnormal Glycan Synthesis and Degradation

gan Kanagawa, Motoi
Cyhoeddwyd yn J Neuromuscul Dis (2019)

Muscular Dystrophy with Ribitol-Phosphate Deficiency: A Novel Post-Translational Mechanism in Dystroglycanopathy

gan Kanagawa, Motoi, Toda, Tatsushi
Cyhoeddwyd yn J Neuromuscul Dis (2017)

Mislocalization of Fukutin Protein by Disease-causing Missense Mutations Can Be Rescued with Treatments Directed at Folding Amelioration

gan Tachikawa, Masaji, Kanagawa, Motoi, Yu, Chih-Chieh, Kobayashi, Kazuhiro, Toda, Tatsushi
Cyhoeddwyd 2012

Contribution of Dysferlin Deficiency to Skeletal Muscle Pathology in Asymptomatic and Severe Dystroglycanopathy Models: Generation of a New Model for Fukuyama Congenital Muscular D...

gan Kanagawa, Motoi, Lu, Zhongpeng, Ito, Chiyomi, Matsuda, Chie, Miyake, Katsuya, Toda, Tatsushi
Cyhoeddwyd 2014

Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure

gan Ujihara, Yoshihiro, Kanagawa, Motoi, Mohri, Satoshi, Takatsu, Satomi, Kobayashi, Kazuhiro, Toda, Tatsushi, Naruse, Keiji, Katanosaka, Yuki
Cyhoeddwyd yn Nat Commun (2019)

Temporal requirement of dystroglycan glycosylation during brain development and rescue of severe cortical dysplasia via gene delivery in the fetal stage

gan Sudo, Atsushi, Kanagawa, Motoi, Kondo, Mai, Ito, Chiyomi, Kobayashi, Kazuhiro, Endo, Mitsuharu, Minami, Yasuhiro, Aiba, Atsu, Toda, Tatsushi
Cyhoeddwyd yn Hum Mol Genet (2018)

Galectin 3–binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein

gan Seki, Tsuneyoshi, Kanagawa, Motoi, Kobayashi, Kazuhiro, Kowa, Hisatomo, Yahata, Naoki, Maruyama, Kei, Iwata, Nobuhisa, Inoue, Haruhisa, Toda, Tatsushi
Cyhoeddwyd yn J Biol Chem (2020)

Posttranslational Modification of α-Dystroglycan, the Cellular Receptor for Arenaviruses, by the Glycosyltransferase LARGE Is Critical for Virus Binding

gan Kunz, Stefan, Rojek, Jillian M., Kanagawa, Motoi, Spiropoulou, Christina F., Barresi, Rita, Campbell, Kevin P., Oldstone, Michael B. A.
Cyhoeddwyd 2005

Post-translational Maturation of Dystroglycan Is Necessary for Pikachurin Binding and Ribbon Synaptic Localization

gan Kanagawa, Motoi, Omori, Yoshihiro, Sato, Shigeru, Kobayashi, Kazuhiro, Miyagoe-Suzuki, Yuko, Takeda, Shin'ichi, Endo, Tamao, Furukawa, Takahisa, Toda, Tatsushi
Cyhoeddwyd 2010

Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression

gan Ohtsuka, Yoshihisa, Kanagawa, Motoi, Yu, Chih-Chieh, Ito, Chiyomi, Chiyo, Tomoko, Kobayashi, Kazuhiro, Okada, Takashi, Takeda, Shin'ichi, Toda, Tatsushi
Cyhoeddwyd yn Sci Rep (2015)

CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan

gan Imae, Rieko, Manya, Hiroshi, Tsumoto, Hiroki, Osumi, Kenji, Tanaka, Tomohiro, Mizuno, Mamoru, Kanagawa, Motoi, Kobayashi, Kazuhiro, Toda, Tatsushi, Endo, Tamao
Cyhoeddwyd yn J Biol Chem (2018)

TRPV2 is critical for the maintenance of cardiac structure and function in mice

gan Katanosaka, Yuki, Iwasaki, Keiichiro, Ujihara, Yoshihiro, Takatsu, Satomi, Nishitsuji, Koki, Kanagawa, Motoi, Sudo, Atsushi, Toda, Tatsushi, Katanosaka, Kimiaki, Mohri, Satoshi, Naruse, Keiji
Cyhoeddwyd 2014

Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy

gan Morioka, Shigefumi, Sakaguchi, Hirofumi, Mohri, Hiroaki, Taniguchi-Ikeda, Mariko, Kanagawa, Motoi, Suzuki, Toshiaki, Miyagoe-Suzuki, Yuko, Toda, Tatsushi, Saito, Naoaki, Ueyama, Takehiko
Cyhoeddwyd yn PLoS Genet (2020)

The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan

gan Manya, Hiroshi, Yamaguchi, Yoshiki, Kanagawa, Motoi, Kobayashi, Kazuhiro, Tajiri, Michiko, Akasaka-Manya, Keiko, Kawakami, Hiroko, Mizuno, Mamoru, Wada, Yoshinao, Toda, Tatsushi, Endo, Tamao
Cyhoeddwyd yn J Biol Chem (2016)

In silico drug screening by using genome-wide association study data repurposed dabrafenib, an anti-melanoma drug, for Parkinson’s disease

gan Uenaka, Takeshi, Satake, Wataru, Cha, Pei-Chieng, Hayakawa, Hideki, Baba, Kousuke, Jiang, Shiying, Kobayashi, Kazuhiro, Kanagawa, Motoi, Okada, Yukinori, Mochizuki, Hideki, Toda, Tatsushi
Cyhoeddwyd yn Hum Mol Genet (2018)

Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment

gan Sugawara, Yumika, Hamada, Keisuke, Yamada, Yuji, Kumai, Jun, Kanagawa, Motoi, Kobayashi, Kazuhiro, Toda, Tatsushi, Negishi, Yoichi, Katagiri, Fumihiko, Hozumi, Kentaro, Nomizu, Motoyoshi, Kikkawa, Yamato
Cyhoeddwyd yn Sci Rep (2019)

Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy

gan Kuwabara, Naoyuki, Imae, Rieko, Manya, Hiroshi, Tanaka, Tomohiro, Mizuno, Mamoru, Tsumoto, Hiroki, Kanagawa, Motoi, Kobayashi, Kazuhiro, Toda, Tatsushi, Senda, Toshiya, Endo, Tamao, Kato, Ryuichi
Cyhoeddwyd yn Nat Commun (2020)

Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors

gan Orlandi, Cesare, Omori, Yoshihiro, Wang, Yuchen, Cao, Yan, Ueno, Akiko, Roux, Michel J., Condomitti, Giuseppe, de Wit, Joris, Kanagawa, Motoi, Furukawa, Takahisa, Martemyanov, Kirill A.
Cyhoeddwyd yn Cell Rep (2018)

Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection

gan Hara, Yuji, Kanagawa, Motoi, Kunz, Stefan, Yoshida-Moriguchi, Takako, Satz, Jakob S., Kobayashi, Yvonne M., Zhu, Zihan, Burden, Steven J., Oldstone, Michael B. A., Campbell, Kevin P.
Cyhoeddwyd 2011

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle

gan Kamizaki, Koki, Doi, Ryosuke, Hayashi, Makoto, Saji, Takeshi, Kanagawa, Motoi, Toda, Tatsushi, Fukada, So-ichiro, Ho, Hsin-Yi Henry, Greenberg, Michael Eldon, Endo, Mitsuharu, Minami, Yasuhiro
Cyhoeddwyd yn J Biol Chem (2017)