CDP-glycerol inhibits the synthesis of the functional O-mannosyl glycan of α-dystroglycan

α-Dystroglycan (α-DG) is a highly glycosylated cell-surface laminin receptor. Defects in the O-mannosyl glycan of an α-DG with laminin-binding activity can cause α-dystroglycanopathy, a group of congenital muscular dystrophies. In the biosynthetic pathway of functional O-mannosyl glycan, fukutin (FK...

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Vydáno v:J Biol Chem
Hlavní autoři: Imae, Rieko, Manya, Hiroshi, Tsumoto, Hiroki, Osumi, Kenji, Tanaka, Tomohiro, Mizuno, Mamoru, Kanagawa, Motoi, Kobayashi, Kazuhiro, Toda, Tatsushi, Endo, Tamao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078450/
https://ncbi.nlm.nih.gov/pubmed/29884773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003197
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