Extracellular Matrix Remodeling During the Progression of Volume Overload-Induced Heart Failure

por Hutchinson, Kirk R., Stewart, James A., Lucchesi, Pamela A.
Publicado 2009

INCREASED MYOCARDIAL STIFFNESS DUE TO CARDIAC TITIN ISOFORM SWITCHING IN A MOUSE MODEL OF VOLUME OVERLOAD LIMITS ECCENTRIC REMODELING

por Hutchinson, Kirk R, Saripalli, Chandra, Chung, Charles S., Granzier, Henk
Publicado en J Mol Cell Cardiol (2014)

Cardiac Fibroblast-Dependent Extracellular Matrix Accumulation Is Associated with Diastolic Stiffness in Type 2 Diabetes

por Hutchinson, Kirk R., Lord, C. Kevin, West, T. Aaron, Stewart, James A.
Publicado 2013

Systemic Maternal Inflammation and Neonatal Hyperoxia Induces Remodeling and Left Ventricular Dysfunction in Mice

por Velten, Markus, Hutchinson, Kirk R., Gorr, Matthew W., Wold, Loren E., Lucchesi, Pamela A., Rogers, Lynette K.
Publicado 2011

The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin’s spring elements

por Hidalgo, Carlos G, Chung, Charles S, Saripalli, Chandra, Methawasin, Mei, Hutchinson, Kirk R, Tsaprailis, George, Labeit, Siegfried, Mattiazzi, Alicia, Granzier, Henk L
Publicado 2012

Experimentally Increasing TITIN Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism but has a Beneficial Effect on Diastole

por Methawasin, Mei, Hutchinson, Kirk R, Lee, Eun-Jeong, Smith, John E, Saripalli, Chandra, Hidalgo, Carlos G, Ottenheijm, Coen AC, Granzier, Henk
Publicado 2014

Myocardial dysfunction in an animal model of cancer cachexia

por Xu, Hui, Crawford, Danielle, Hutchinson, Kirk R., Youtz, Dane J., Lucchesi, Pamela A., Velten, Markus, McCarthy, Donna O., Wold, Loren E.
Publicado 2010

IN VIVO AND IN VITRO CARDIAC RESPONSES TO BETA-ADRENERGIC STIMULATION IN VOLUME-OVERLOAD HEART FAILURE

por Guggilam, Anuradha, Hutchinson, Kirk R, West, A Thomas, Kelly, Amy P, Galantowicz, Maarten L, Davidoff, Amy J, Sadayappan, Sakthivel, Lucchesi, Pamela A
Publicado 2012

Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction

por Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
Publicado 2013

Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure

por Hutchinson, Kirk R., Guggilam, Anuradha, Cismowski, Mary J., Galantowicz, Maarten L., West, Thomas A., Stewart, James A., Zhang, Xiaojin, Lord, Kevin C., Lucchesi, Pamela A.
Publicado 2011

Cardiovascular Remodeling in Response to Long-Term Exposure to Fine Particulate Matter Air Pollution

por Wold, Loren E., Ying, Zhekang, Hutchinson, Kirk R., Velten, Markus, Gorr, Matthew W., Velten, Christina, Youtz, Dane J., Wang, Aixia, Lucchesi, Pamela A., Sun, Qinghua, Rajagopalan, Sanjay
Publicado 2012

Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

por Granzier, Henk L., Hutchinson, Kirk R., Tonino, Paola, Methawasin, Mei, Li, Frank W., Slater, Rebecca E., Bull, Mathew M., Saripalli, Chandra, Pappas, Christopher T., Gregorio, Carol C., Smith, John E.
Publicado 2014

Coronary Arterioles in Type 2 Diabetic (db/db) Mice Undergo a Distinct Pattern of Remodeling Associated with Decreased Vessel Stiffness

por Katz, Paige S., Trask, Aaron J., Souza-Smith, Flavia M., Hutchinson, Kirk R., Galantowicz, Maarten L., Lord, Kevin C., Stewart, James A., Cismowski, Mary J., Varner, Kurt J., Lucchesi, Pamela A.
Publicado 2011

Early heart failure in the SMNΔ7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

por Bevan, Adam K., Hutchinson, Kirk R., Foust, Kevin D., Braun, Lyndsey, McGovern, Vicki L., Schmelzer, Leah, Ward, Jennifer G., Petruska, Jeffrey C., Lucchesi, Pamela A., Burghes, Arthur H.M., Kaspar, Brian K.
Publicado 2010

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

por Pappas, Christopher T., Mayfield, Rachel M., Henderson, Christine, Jamilpour, Nima, Cover, Cathleen, Hernandez, Zachary, Hutchinson, Kirk R., Chu, Miensheng, Nam, Ki-Hwan, Valdez, Jose M., Wong, Pak Kin, Granzier, Henk L., Gregorio, Carol C.
Publicado en Proc Natl Acad Sci U S A (2015)