Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function

Titin, the largest protein known, forms a giant filament in muscle where it spans the half sarcomere from Z disk to M band. Here we genetically targeted a stretch of 14 immunoglobulin-like and fibronectin type 3 domains that comprises the I-band/A-band (IA) junction and obtained a viable mouse model...

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Detalhes bibliográficos
Main Authors: Granzier, Henk L., Hutchinson, Kirk R., Tonino, Paola, Methawasin, Mei, Li, Frank W., Slater, Rebecca E., Bull, Mathew M., Saripalli, Chandra, Pappas, Christopher T., Gregorio, Carol C., Smith, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210014/
https://ncbi.nlm.nih.gov/pubmed/25246556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411493111
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